Effects of some sulfur-containing antioxidants on lead-exposed lenses.

نویسندگان

  • R Neal
  • K Cooper
  • G Kellogg
  • H Gurer
  • N Ercal
چکیده

Lead (Pb) is known to negatively affect glutathione (GSH) metabolism in the lens. The present study examined the effects of Captopril, Taurine, and alpha-Lipoic acid on the Pb-induced GSH depletion and lipid peroxide increase in the lenticular system. Captopril administration returned the GSH, cysteine (CYS), and malondialdehyde (MDA) levels to near normal. Following Taurine administration the GSH, CYS and MDA levels were intermediate between the control group and the Pb group levels. Alpha-Lipoic acid administration, however, only increased the CYS levels. No significant changes in oxidized glutathione (GSSG) levels were observed in any treatment group.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Concentration of Thyroid Hormones, Cortisol and ACTH Exposed to Chemical Weapons

  ABSTRACT In order to evaluate time course of changes in serum concentration of thyroid hormones, cortisol and ACTH in patients exposed to chemical weapons containing sulfur mustard, we measured serum concentrations of hormones on the first, third and fifth week following injury in 13 soldiers and compared them to the results obtained from 34 control men. Free T4 and T3 indices were decrease...

متن کامل

Antioxidant effects of sulfur-containing amino acids.

Sulfur is an essential element for the entire biological kingdom because of its incorporation into amino acids, proteins and other biomolecules. Sulfur atoms are also important in the iron-containing flavoenzymes. Unlike humans, plants can use inorganic sulfur to synthesize sulfur-containing amino acids. Therefore, plants are an important source of sulfur for humans. Sulfur-containing compounds...

متن کامل

Radioprotective Effects of Sulfur-containing Mineral Water of Ramsar Hot Spring with High Natural Background Radiation on Mouse Bone Marrow Cells

Background: We intend to study the inhibitory effect of sulfur compound in Ramsar hot spring mineral on tumor-genesis ability of high natural background radiation. Objective: The radioprotective effect of sulfur compounds was previously shown on radiation-induced chromosomal aberration, micronuclei in mouse bone marrow cells and human peripheral lymphocyte. Ramsar is known for having the highe...

متن کامل

Study of the Effects of Hexamethylentetramine on Decrease of Defects of the Lung Tissue in the Rat Exposed to Sulfur Mustard

Purpose: The aim of this study was to evaluate the effects of HMT on protection of lung tissue exposed to HD in the rat. Materials and Methods: In this study twenty Albino Wister adult male rats weighting 200±20 gram were used. Rats divided randomly into 4 groups (each group has 5 rats) as below: Normal saline group (NS), HMT group, HD group (0.25% HD) and HD+HMT group. Normal saline and HD sol...

متن کامل

Potential role of sulfur-containing antioxidant systems in highly oxidative environments.

All forms of life maintain a reducing environment (homeostasis) within their cells. Perturbations in the normal redox state can lead to an oxidative environment which has deleterious effects, especially in health. In biological systems, metabolic activities are dependent mainly on mitochondrial oxidative phosphorylation, a metabolic pathway that uses energy released by the oxidation of nutrient...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Free radical biology & medicine

دوره 26 1-2  شماره 

صفحات  -

تاریخ انتشار 1999